Proliferating Cell
Nuclear Antigen is the ring-shaped homotrimeric eukaryotic sliding clamp
processivity factor. It can bind to Polymerases and tether them to the primer terminus.
PCNA has been
implicated in translesion synthesis, specifically polymerase
exchange.
However, much of the
molecular mechanisms for these interactions remains unknown.
Image by Boghog - Own work, Public Domain, https://commons.wikimedia.org/w/index.php?curid=12422719
Basic
Structure of PCNA |
Page 1 |
Ubiquitinated
PCNA |
Page 2 |
PCNA complexed
with DNA |
Page 3 |
PCNA + Pol K |
Page 4 |
PCNA + Pol I | Page 5 |
PCNA + Pol η | Page 6 |