An Interactive Jmol Tutorial about PCNA

Proliferating Cell Nuclear Antigen is the ring-shaped homotrimeric eukaryotic sliding clamp

processivity factor.  It can bind to Polymerases and tether them to the primer terminus.

PCNA has been implicated in translesion synthesis, specifically polymerase exchange. 

However, much of the molecular mechanisms for these interactions remains unknown.

Image by Boghog - Own work, Public Domain, https://commons.wikimedia.org/w/index.php?curid=12422719

Basic Structure of PCNA
Page 1
Ubiquitinated PCNA
Page 2
PCNA complexed with DNA
Page 3
PCNA + Pol K
Page 4
PCNA + Pol I Page 5
PCNA + Pol η  Page 6