An Interactive Jmol
Tutorial about Beta-catenin
B-catenin is
essential for cadherin-based cell adhesion and the central effector of
the canonical Wnt signaling pathway. It also binds to Tcf-family and the
tumor suppressor gene product Adenomatous Polypisis Coli (APC).
B-catenin engages in critical protein-protein interactions by using the
groove in the armadillo repeat region that serve as a common binding
site for several b-catenin-binding partners.
| Beta-catenin
structure |
Page
1 |
B-catenin
Armadillo repeat
|
Page
2 |
B-catenin
E-cadherin interaction
|
Page
3 |
B-catenin Tcf
interaction
|
Page
4 |
B-catenin APC
interaction
|
Page
5 |
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