AcrB is the major efflux protein of Escherichia
coli driven
by proton motive force. Along
with TolC membrane channel, AcrB participate in extruding number of
antimicrobial agents out of cell resulting multi drug resistance. The
natural function of the this protein involves pumping
out
of bile salts and their derivatives to survive in the presence of the
high concentrations of these detergents in the natural habitat of
E.
coli.
Numerous studies have been carried out to study the structure to gain
insights for designing and discovering drugs to inhibit AcrB.
| Protomer structure of AcrB, composed of 3 domains | Page 1 |
| Side view of Pore and TolC docking domains | Page 2 |
| Structure related to the function of AcrB | Page 3 |
| Residues interacting with Monocyclinin | Page 4 |
| Residues interacting with Doxorubicin | Page 5 |
| Residues interacting with MBX2931 | Page 6 |
| Comparison of Monocyclin and MBX2931 to binding pocket | Page 7 |